Sequential polypeptides endowed with immunological activity

Details Sequential polypeptides endowed with immunological activity Sequential polypeptides endowed with immunological activity

1988-08-02

1993-06-15

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530329, 424 88, A61K 3702, C07K 706, C07K 708/7/10

Patent

active

052199878

ABSTRACT:
Synthetic polypeptides constituted by at least two consecutive repeating units of (Asn-Asn-Pro) sequence are powerful immunogens in test animals.
The formed antibodies recognize both the synthetic polypeptides and the immuno-dominant epitope of the circumsporozoitic protein of Plasmodium falciparum.
Said polypeptides, which can be obtained in pure form, are particularly useful for the preparation of antimalarial vaccines and of diagnostic kits for the determination of malarial affections.

REFERENCES:
patent: 3929756 (1975-12-01), Leeman et al.
patent: 4132746 (1979-06-01), Urry et al.
patent: 4409141 (1983-11-01), Noda et al.
patent: 4707357 (1987-11-01), Dame et al.
patent: 4843146 (1989-06-01), Bernardi et al.
Chou, Peter Y, et al., Ann. Rev. Biochem., 47: 251-76, 1978.
Hopp, Thomas P., J. of Immun. Methods, 88: 1-18, 1986.
Chou & Fasman Algorithm, Intelli Genetics.

Affiliated with

Also associated with

Rating

Sequential polypeptides endowed with immunological activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sequential polypeptides endowed with immunological activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sequential polypeptides endowed with immunological activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1044016