Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-05-18
1994-01-18
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 536 127, 536 231, 536 243, 536 2433, 536 254, C12Q 168, C12P 1934, C07H 504, C07H 1700
Patent
active
052799387
ABSTRACT:
The nucleotide sequence of a recombinant clone containing a specific segment of Borrelia burgdorferi DNA which enables the identification of the spirochetes causing Lyme disease has been provided. A diagnostic kit containing oligonucleotide primers derived from this sequence, suitable for the detection of Borrelia burgdoferi in a PCR assay, as well as the cloned DNA of the present invention, allows the detection of Lyme disease with sensitivity and specificity not heretofore attained by any other test.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
Schwan et al., "Ethiacy of Nucleic Acid Hybridization Probes . . . " Annals of the N.Y. Academy of Science, vol. 539, pp. 419-420.
Goodman et al., "A Unique DNA Clone Specific for Borrelia . . . " Clin. Res. vol. 37(2) 1989.
Rosa, et al., "A Specific and Sensitive Assay for the Lyme Disease Spirochete Borretia burgdorferi Using the Polymerase Chain Reaction", The Jour. of Infect. Dis., vol. 160, No. 6, Dec., 1989, pp. 1018-1029.
Schwan, et al., "Efficacy of Nucleic Acid Hybridizaation Probes for the Detection and Identification of Borrelia burgdorferi" Annals of the N.Y. Academy of Sciences, vol. 539, pp. 419-421 (1988).
Goodman, et al., "A Unique DNA Clone Specific for Borrelia burgdoferi: Preliminary Hybridization and Sequence Analysis" Clin. Res., vol. 37 (2), pp. 429A (1989).
Rosa, et al., "A Specific and Sensitive Assay for the Lyme Disease Spirochete Borrelia burgdorferi Using the Polymerase Chain Reaction", J. of Infect. Dis., vol. 160 (6), pp. 1018-1029 (Dec. 1989).
Escully Miguel
The United States of America as represented by the Department of
Wax Robert A.
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