Selenium derivatives of thyroxine and tri-iodothyronine

Details Selenium derivatives of thyroxine and tri-iodothyronine Selenium derivatives of thyroxine and tri-iodothyronine

1980-01-30

1982-01-19

Demers, Arthur P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 40, 564165, C07C10108, C07C16300

Patent

active

043118534

ABSTRACT:
Novel Selenium derivatives of thyroxine and tri-iodothyronine have the formula: ##STR1## wherein M is I or H and either (a) R.sub.1 is OH or a carboxyl protecting group and R.sub.2 contains at least one Se, preferably .sup.75 Se, atom or (b) R.sub.2 is H or an amino protecting group and R.sub.1 contains at least one Se, preferably .sup.75 Se, atom.
The compounds are useful in dual isotope assays of thyroid function.

REFERENCES:
patent: 2579668 (1951-12-01), Hems et al.
patent: 3930017 (1975-12-01), Kummer et al.
patent: 4065554 (1977-12-01), Tilly et al.
patent: 4139605 (1979-02-01), Felder et al.
Paxton et al., Clin. Chem., 24/9, (1978), pp. 1534-1538.

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