Selective nitrogen functionalization of organic compounds

Details Selective nitrogen functionalization of organic compounds Selective nitrogen functionalization of organic compounds

2002-01-01

2002-08-27

Kumar, Shailendra (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S188000, C564S189000, C564S215000, C564S217000

Reexamination Certificate

active

06441232

ABSTRACT:

The invention relates to a method for the selective replacement of a carbon-hydrogen bond at an unactivated, saturated sp3 carbon atom in an organic compound by a carbon-nitrogen bond.
The search for efficient methodology for the selective conversion of alkanes to functionalised derivatives has been the focus of substantial effort from many research groups worldwide over the last 20 years (C. L. Hill, Eds.,
Activation and Functionalisation of Alkanes
, Wiley, New York, 1989). Alkanes constitute roughly half of the mass of crude oil and, therefore, a vast resource of raw material is potentially available for chemical synthesis but, at present, most of the world's alkane resources are simply burnt to provide heat and energy or, in the case of the lower alkanes, destroyed at the point of extraction.
Effective processes for the transformation of hydrocarbons to functionalised derivatives are urgently required and many approaches have been investigated in attempts to put the earth's fossil fuels to better use. Potential solutions to carbon-hydrogen bond activation have included use of the Gif/GoAgg oxidation method (typically comprising mixtures of iron, pyridine, acetic acid and hydrogen peroxide) devised by Barton (D. H. R. Barton and D. Doller,
Acc Chem. Res
., 1992, 25, 504), use of highly electrophilic reagents or superacids by Olah (G. A. Olah.
Acc. Chem. Res
., 1987,20,422), use of transition metal catalysts (R. A. Periana, D. J. Taube, S. Gamble, H. Taube, T. Satoh and H Fujii,
Science
, 1998, 280, 560), use of metalloporphyrin catalysts (J. T. Groves, M. Bonchio, T. Carofiglio and K. Shalyaev,
J. Am. Chem. Soc
., 118,8961), use of enzymatic (Cytochrome P-450) and use of biomimetic oxidation procedures (R. Breslow, X. Zhang and Y. Huang,
J. Am. Chem. Soc
., 1997. 119, 4535). However, low yields, long reaction times, lack of selectively and high expense, limit the use of many of these approaches. In general, the functionalised alkane products are typically more reactive than the alkane starting materials and so reactions must be carried out to very low conversion in order to minimise by-product formation.
Halogenation processes, most commonly using molecular chlorine, have been intensively studied (Olah,
Hydrocarbon Chemistry
, John Wiley and Sons 1995). Both thermal and photochemical chlorination processes are well established and are usually operated at high temperature (>300° C.) in the vapour phase. However, due to the harsh reaction environment, free radical chlorination of hydrocarbons is, in general, a totally non-selective process and gives all possible monochlorinated products limiting the utility of this methodology.
The transformation of unactivated sp3 hybridised carbon-hydrogen bonds in saturated systems to carbon-nitrogen bonds, i.e. nitrogen functionalisation, represents a significant synthetic challenge. Nitration of alkanes (Olah,
J. Am. Chem. Soc
., 1971, 93, 1259) can be accomplished using nitronium tetrafluoroborate in superacidic solution but carbon-carbon bond cleavage is a significant competing process which leads to low yields of nitro-alkane derivatives. Amination of alkanes (Mahy,
New. J. Chem
., 1989, 13, 651) has been achieved using porphyrin catalysed reaction of tosylimidoiodobenzene to give tosylamino-hydrocarbon products. The use of harsh reaction conditions, high expense and low efficiency precludes the use of these processes on a large scale.
It is an object of the invention to provide a method of transforming unactivated sp3 hybridised carbon-hydrogen bonds to carbon-nitrogen bonds in which the aforementioned problems are reduced or eliminated.
According to the invention there is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a solvent reaction medium comprising a nitrile compound and providing a Lewis acid whereby the carbon-hydrogen bond is replaced by a carbon-nitrogen bond.
Advantageously, the present invention provides a method for transforming unactivated sp3 hybridised carbon-hydrogen bonds to carbon-nitrogen bonds, i.e. nitrogen functionalisation, by a high yielding, economically feasible process.
Advantageously, the reaction may be carried out using readily available and inexpensive reagents.
Advantageously, the reaction may be performed in one stage and/or in one vessel.
Advantageously, the method may be carried out at or just below ambient or room temperature.
Accordingly, the invention provides a significant improvement in direct selective nitrogen functionalisation processes over the prior art.
The term unactivated saturated sp3 carbon atom used herein means a saturated sp3 hybridised carbon atom not directly bonded to any functional group. That is to say, any carbon atom which is part of a functional group (e.g. carbonyl C═O) or is bearing a functional group (e.g. C—OH) must be at least two atoms distant from the carbon which is bonded to the hydrogen atom that is replaced by a nitrogen atom. In the prior art, functional groups such as for example carbonyl were directly bonded, i.e. less than two carbons distant, to the carbon atom which is bonded to the hydrogen atom that is replaced. Thus, in the prior art, the functional group would activate the carbon-hydrogen bond on the saturated carbon atom.
Preferably, the fluorinating agent comprises elemental fluorine gas. Fluorine gas is readily available and cheap.
Preferably the fluorine gas is diluted before use by mixing with an inert gas such as helium or nitrogen. The concentration of fluorine in the inert gas may be from 1% to 50% by volume, preferably from 2% to 25% by volume and especially from 5% to 15% by volume.
The ratio of fluorine gas to organic compound to be fluorinated may be varied within wide limits although it is preferred that the molar ratio is in the range 0.5 to 10:1 and more preferred that is 1 to 3:1.
The invention may be carried out by passing fluorine gas into a mixture containing the organic compound, the Lewis acid and the nitrile containing solvent in a suitable vessel. To ensure complete conversion of substrate to the corresponding N-functionalised derivative the reaction mixture can, if necessary, be heated externally, to a temperature ranging from 30° C. to 80° C., preferably 50-60° C., after the passage of fluorine gas. Alternatively, a flowing stream of the mixture may be contacted with a gaseous flow of fluorine in counter current or co-current fashion.
Alternatively, the invention may be carried out by passing elemental fluorine gas into a mixture containing the organic compound and the nitrile containing solvent in a suitable vessel. After passage of the fluorine, the Lewis acid, preferably boron trifluoride, is added to the reaction mixture at room temperature and stirred. A flowing stream of the mixture may be contacted with a gaseous flow of fluorine in counter-current or co-current fashion.
Alternatively, the invention may be carried out using a fluorinating agent which comprises a compound containing an N—F bond. The fluorinating agent may, in particular, comprise one of the following: an N-fluoropiperidine, an N-fluoropyridone, an N-fluorosulphonamide, an N-fluoropyridinium salt, an N-fluoroimide or an N-fluorodiazabicycloalkane or similar reagents. When an N—F fluorinating reagent is used, the invention may be carried out by heating a mixture consisting of the N—F fluorinating reagent, the substrate, a Lewis acid as required and the nitrile containing solvent in a suitable vessel. The compound containing an N—F bond may itself provide the Lewis acid.
Where the fluorinating agent comprises a compound containing an N—F bond, preferably, the fluorinating agent comprises an N-fluorinated diazoniabicycloalkane, i.e. one of the class of reagents known commercially as Selectfluor (Trade mark) reagents. In such cases, more preferably the fluorinating agent is an N-fluorinated 1,4,diazoniabicyclo-(2.2.2) octane derivative an

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