Selective acetylcholinesterase inhibitors and methods of making

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbonate esters

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558273, C07C 6996

Patent

active

050829645

ABSTRACT:
A new group of alpha substituted cresol choline carbonate salts, that act as site-specific, irreversible inhibitors of acetylcholinesterase. A halomethylation method and a halogenation method for producing said alpha substituted cresol choline carbonate salts and analogs thereof. Methods of using the inhibitors as anticholinergic insecticides and to reduce acetylcholinesterase activity levels in organisms with excessive levels of acetylcholinesterase.

REFERENCES:
patent: 3134802 (1964-05-01), Gaertner et al.
patent: 3420868 (1969-01-01), Weil
patent: 3598856 (1971-08-01), Fujino et al.
patent: 4260529 (1981-04-01), Letton

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