Selectable vectors for human T cells

Details Selectable vectors for human T cells Selectable vectors for human T cells

1992-09-18

2000-02-15

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 914, 435 9141, 4353201, 435366, 435372, 4353723, 435455, 435456, 435462, 435463, C12P 2100, C12N 1586, C12N 1564

Patent

active

060251530

ABSTRACT:
Selectable Herpesvirus saimiri vectors which have a selection gene inserted into a junction region of the L- and H-DNA are described. Vectors of this type are able persistently to infect human T cells and thus are suitable for the expression of foreign genes in human T cells. An additional advantage is that no infectious virus particles are produced during this.

REFERENCES:
Fleckenstein et al., The Herpesviruses, v. 1, B. Roizman, ed., 1982, Plenum Publishing Co., New York.
Desrosiers et al., J. Virol 49(2):343-348 (1984).
Grassman and Fleckenstein, J. Virol. 63(4):1818-1821 (Apr. 1989).
Grassman et al., Proc. Nat'l Acad. Sci. USA 86:3351-3355 (May 1989).
Southern and Berg, J. Mol. and App. Gen. 1:327-341 (1982), Transformation of Mammalian Cells to Antibiotic Resistance with a Bacterial Gene Under Control of the SV40 Early Region Promoter.
Desrosiers et al., Mol. and Cell. Biol. 5(10) 2796-2803 (1985), Synthesis of Bovine Growth Hormone in Primates by Using a Herpesvirus Vector.
Schneider et al., Int. J. Cancer 19:621-26 (1977), Characterization of EBV-Genome Negative "Null" and "T" Cell Lines Derived From Children With Acute Lymphoblastic Leukemia and Leukemic Transformed Non-Hodgkin Lymphoma.
Fleckenstein et al., J. Virol. 15(2) 398-406 (1975), Repetitive Sequences in Complete and Defective Genomes of Herpesvirus saimiri.
Bankier, et al., J. Virol. 55(1) 133-39 (1985), Terminal Repetitive Sequences in Herpesvirus saimiri Virion DNA.
Graham and Van Der Eb, Virology 52:456-67 (1973), A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA.
Knust et al., Gene 25:281-89 (1983), Cloning of Herpesvirus saimiri DNA fragments representing the entire L-region of the genome.

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