Secreted and transmembrane polypeptides and nucleic acids...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S325000, C435S252300, C435S006120, C530S350000, C536S024300

Reexamination Certificate

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06946262

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: 6284485 (2001-09-01), Boyle et al.
patent: 6590075 (2003-07-01), Ruben et al.
patent: WO 99/43802 (1999-09-01), None
Lawrence et al. Comparison of DX-8951f and topotecan effects on tumor colony formation from freshly explanted adult and pediatric human tumor cells. Anti-Cancer Drugs 10:655-661(1999).
Hanauske et al. Adenocarcinoma of unknown primary:retrospective analysis of chemosensitivity of 313 freshly explanted tumors in a tumor cloning system. Investigational New Drugs 13: 43-49 (1995).
Kornblith et al. In Vitro Responses of Ovarian Cancers to Platinums and Taxanes. Anticancer Research 23:543-548(2003).
Depenbrock et al. Preclinical Activity of Trans-indazolium [Tetrachlorobisindazoleruthenate(III)](NSC 666158;IndCR;KP1019) Against Tumor Colony-forming Units and Haematopoietic Progentitor Cells. European Journal of Cancer 33:2404-2410 (1997).
Barber et al., “The Receptor for Yolk Lipoprotein Deposition in the Chicken Oocyte,”The Journal of Biological Chemistry266(28): 18761-18770 (1991).
Huang et al., “NMR Solution Structure of Complement-like Repeat CR8 from the Low Density Lipoprotein Receptor-related Protein,”The Journal of Biological Chemistry274(20): 14130-14136 (1999).
42 human EST's putatively encoding proteins having similarity with lipoprotein receptors disclosed before Sep. 17, 1997; Host: NCBI Database: Genbank.
500 human EST's putatively encoding secreted or transmembrante proteins disclosed before Oct. 28, 1997; Host; NCBI, Database: Genbank.
Lestraval and Fruchart, “Lipoprotein receptors”, Cell. Mol. Biol. 40 (4), pp. 461-481, 1994.

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