Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-05-21
1989-09-05
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549265, 549271, 549267, A61K 31365, C07D30312, C07D31308
Patent
active
048639559
ABSTRACT:
Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.
REFERENCES:
patent: 4342751 (1982-08-01), Moore et al.
Chemical Abstracts (1987) 106:153049e, Moore et al., "Scgtophycins Potent Cytotonic Macrolides from Glue-Green Algae".
M. Ishibashi et al., J. Org. Chem. (1986) 51, 5300-5306, "Scytophycins, Cytotoxic and Antimycotic Agents from the Cytcinophyte Scytonema Pseudshofmanni".
S. Carmely et al., "Structure of Swinholide-A, A New Macrolide from the Marine sponge Theonella Swinhoei", Tetrahedron Letters 1985, 511-514.
R. E. Moore in Marine Natural Products: Chemical and Biological Perspectives, P. J. Scheuer, ed., vol. IV, pp. 30-34, Academic Press, New York (1981).
R. E. Moore, "Toxins from Blue-Green Algae", BioScience 27 (12), 797-802.
R. E. Moore et al., "Toxins from Cyanophytes Belonging to the Scytonemataceae," Pure & Appl. Chem. 58 (2), 263-271 (1986).
J. A. Roesener et al., "Ulapualide A and B, Extraordinary Antitumor Macrolides from Nudibranch Eggmasses," J. Am. Chem. Soc. 1986, 108, 846-847.
S. Matsunaga et al., "Kabiramide C, a Novel Antifungal Macrolide from Nudibranch Eggmasses," J. Am. Chem. Soc. 1986, 108, 847-849.
Furusawa Eiichi
Moore Richard E.
Mynderse Jon S.
Norton Ted R.
Patterson Gregory M. L.
Eli Lilly and Company
Harrison Nancy J.
Hollrah Glennon H.
Russell Mark W.
University of Hawai'i
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