Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-07-01
2008-07-01
Horlick, Kenneth R. (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500
Reexamination Certificate
active
07393940
ABSTRACT:
A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of:(a) obtaining a test sample comprising a nucleotide sequence comprised in the MYH gene of the individual or an amino acid sequence of a polypeptide expressed thereby; and(b) comparing a region of the test sample sequence with the corresponding region of the wild type sequence,whereby a difference between the test sample sequence and the wild type sequence signifies that the individual is pre-disposed to having the cancer; and wherein the difference comprises a specified variation.
REFERENCES:
patent: 6013473 (2000-01-01), Wei
patent: 6051222 (2000-04-01), Wei
patent: 6639063 (2003-10-01), Edwards et al.
patent: WO 97/33903 (1997-09-01), None
patent: WO 03/014390 (2003-02-01), None
Product #1256, Random Primer 24, New England Biolabs Catalog (1998-1999) p. 121.
Martin et al. Lemur catta clone LB2-195A23, Working Draft Sequence, 23 ordered pieces. GenBank Accession No. AC118575 (2002).
Al-Tassan et al., “Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors”,Nature Genetics,Feb. 2002, 30:227-232.
Audebert et al., “Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein”,Nucleic Acids Research,2000, 28(14):2672-2678.
Boiteux et al., “The Human OGG1 Gene: Structure, Functions, and Its Implication in the Process of Carcinogenesis”,Archives of Biochemistry and Biophysics,May 1, 2000, 377(1):1-8.
Fearnhead et al., “The ABC of APC”,Human Molecular Genetics,2001, 10(7):721-733.
Gu et al., “Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria”,Nucleic Acids Research,2001, 29(12):2666-2674.
Jones et al., “Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C→ T: A mutations”,Human Molecular Genetics,Nov. 1, 2002, 11(23):2961-2967.
Nakabeppu, Yusaku, “Molecular genetics and structural biology of human MutT homolog, MTH1”,Mutation Research,2001, 477:59-70.
Ohtsubo et al., “Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria”,Nucleic Acids Research,2000, 28(6):1355-1364.
Shinmura et al., “Infrequent Mutations of the hOGG1 Gene, That Is Involved in the Excision of 8-Hydroxyguanine in Damaged DNA, in Human Gastric Cancer”,Jpn. J. Cancer Research,Aug. 1998, 89:825-828.
Shinmura et al., “Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA”,Cancer Letters, 2001, 166:65-69.
Slupska et al., “Cloning and Sequencing a Human Homolog (hMYH) of theEscherichia colimutY Gene Whose Function Is Required for the Repair of Oxidative DNA Damage”,Journal of Bacteriology,Jul. 1996, 178(13)3885-3892.
Sugimura et al., “hOGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility”,Cancer Epidemiology, Biomarkers&Prevention,Aug. 1999, 8:669-674.
Tsuzuki et al., “Analysis of MTH1 gene function in mice with targeted mutagenesis”,Mutation Research,2001, 477:71-78.
Wikman et al., “hOGG1 Polymorphism and Loss of Heterozygosity (LOH): Significance for Lung Cancer Susceptibility in a Caucasian Population”,Int. J. Cancer,2000, 88:932-937.
Cheadle Jeremy P.
Sampson Julian R.
Gibbs Andrew
Horlick Kenneth R.
Myriad I.P. Dept.
Thomas David C.
University of Wales
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