Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
1998-11-02
2001-10-16
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S252300, C435S325000, C536S023100, C536S023500
Reexamination Certificate
active
06303333
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be agonists, antagonists and /or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides.
BACKGROUND OF THE INVENTION
The drug discovery process is currently undergoing a fundamental revolution as it embraces ‘functional genomics’, that is, high throughput genome- or gene-based biology. This approach as a means to identify genes and gene products as therapeutic targets is rapidly superceding earlier approaches based on ‘positional cloning’. A phenotype, that is a biological function or genetic disease, would be identified and this would then be tracked back to the responsible gene, based on its genetic map position.
Functional genomics relies heavily on high-throughput DNA sequencing and the various tools of bioinformatics to identify gene sequences of potential interest from the many molecular biology databases now available. There is a continuing need to identify and characterise further genes and their related polypeptides/proteins, as targets for drug discovery.
SUMMARY OF THE INVENTION
The present invention relates to SBHWSB2, in particular SBHWSB2 polypeptides and SBHWSB2 polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of cancer, obesity, inflammatory disorders, heart disease, Crohn's diseases, neuropathies and immune disorders hereinafter referred to as “the Diseases”, amongst others In a further aspect, the invention relates to methods for identifying agonists and antagonists/inhibitors using the materials provided by the invention, and treating conditions associated with SBHWSB2 imbalance with the identified compounds In a still further aspect, the invention relates to diagnostic assays for detecting diseases associated with inappropriate SBHWSB2 activity or levels.
REFERENCES:
patent: WO 98/20023 (1998-05-01), None
patent: WO 99/03993 (1999-01-01), None
Hillier et al. EST Accession No. W47621, Oct. 1996.*
EMBL Accession No. AF038187, Jan. 23, 1998.
Copy of EP Search Report 98203654.3, Aug. 10, 1999.
Hilton et al. “Twenty proteins containing a C-terminal SOCS box form five structural classes”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 114-119 (1998).
GenBank Accession No. AF033188, Jan. 13, 1998.
GenBank Accession No. T74003, Mar. 21, 1995.
GenBank Accession No. AA083653, Jan. 14, 1997.
GenBank Accession No. R59950, May. 29, 1995.
GenBank Accession No. R58013, May 29, 1995.
GenBank Accession No. AA776641, Feb. 6, 1998.
GenBank Accession No. AA147416, Dec. 14, 1996.
Michalovich David
Shaikh Narjis
Sims Matthew Alan
Carlson Karen Cochrane
King William T.
Lawrence Mark
Mitra Rita
Ratner & Prestia
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