Samarium-145 and its use as a radiation source

Details Samarium-145 and its use as a radiation source Samarium-145 and its use as a radiation source

1986-12-08

1989-09-05

Gron, Teddy S.

Surgery

Radioactive substance applied to body for therapy

Radioactive substance placed within body

424 11, A61N 512

Patent

active

H00006696

ABSTRACT:
The present invention covers a new radiation source, samarium-145, with radiation energies slightly above those of I-125 and a half-life of 340 days. The samarium-145 source is produced by neutron irradiation of SM-144. This new source is useful as the implanted radiation source in photon activation therapy of malignant tumors to activate the stable I-127 contained in the IdUrd accumulated in the tumor, causing radiation sensitization and Auger cascades that irreperably damage the tumor cells. This new source is also useful as a brachytherapy source.

REFERENCES:
patent: 4434788 (1984-03-01), Nakatsugawa et al.
patent: 4445225 (1984-04-01), White
patent: 4510924 (1985-04-01), Gray
patent: 4566114 (1986-01-01), Watt et al.
patent: 4702228 (1987-10-01), Russell et al.
Fairchild et al, Workshop on Photon Activation Therapy, BNL Report 51997, Apr. 18, 1985.
Fairchild et al, "Photon Activation Therapy", Strahlentherapie, 160, 1984, pp. 758-763.
Fairchild et al, Investigative Radiology, Jul.-Aug., 1982, vol. 17, No. 4, pp. 407-415.

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