Salts and polymorphs of a pyrrole-substituted indolinone...

Details Salts and polymorphs of a pyrrole-substituted indolinone... Salts and polymorphs of a pyrrole-substituted indolinone...

2007-07-24

2007-07-24

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S106000, C544S111000, C544S141000, C544S144000, C514S231200, C514S232800, C514S233500

Reexamination Certificate

active

10956420

ABSTRACT:
The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.

REFERENCES:
patent: 6573293 (2003-06-01), Tang et al.
patent: 6653308 (2003-11-01), Guan et al.
patent: 2003/0069298 (2003-04-01), Hawley et al.
patent: 2003/0092914 (2003-05-01), Guan et al.
patent: 2003/0229229 (2003-12-01), Jin et al.
patent: WO02/066463 (2002-08-01), None
patent: WO2004/024127 (2004-03-01), None

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