S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

Details S type 2-substituted hydroxy-2-indolidinylbutyric ester compound S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

1997-10-28

1999-08-03

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 48, 546 92, 546141, 546 15, 548492, C07D49120, C07D49122

Patent

active

059327324

ABSTRACT:
A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ##STR1## wherein R.sup.o is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen atom is protected), R.sup.1 and R.sup.2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises ##STR2## wherein the symbols are as defined above.

REFERENCES:
A. Ejima et al., "Antitumor Agents, Part 2. Asymmetric Synthesis of (S)-Camptothecin" No. 1, 1990, pp. 27-31, XP002010690.
E.A. Mash, S.B. Hemperly: "Mechanistic Studies of Disastereoselective Cyclopropanation via Homochiral Ketals. 2. Studies with Conformationally Restricted 2-Cyclohexene-1-one Ketals", vol. 55, No. 7, 1990, pp.2055-2060, XP002054434.
A. Ejima et al., "Asymmetric Synthesis of (S)-Camptothecin" Tetrahedron Lett, vol. 30, No. 20, 1989, pp. 2639-2640, XP002054435.
A. Ejima et al., "Antitumor Agents v. Synthesis and Antileukemic Activity of E-Ring-Modified (RS)-Camptothecin Analogues" Chem. Pharm. Bull., vol. 40, No. 3, 1992, pp. 683-688, XP000653713.
Bioorganic & Medicinal Chemistry Lettter, vol. 5, No. 24, pp. 3063-3066, 1995.
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Journal of Medicinal Chemistry, 1980, vol. 23, pp. 554-560.
Journal of Medicinal Chemistry, 1991, vol. 34, pp. 98-107.
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