Truncated human serum albumin polypeptides as plasma expanding a

Details Truncated human serum albumin polypeptides as plasma expanding a Truncated human serum albumin polypeptides as plasma expanding a

1992-02-14

1995-01-10

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530363, 530364, 435 696, A61K 3702

Patent

active

053807120

ABSTRACT:
Polypeptides corresponding to mature human serum albumin residues 1 to n, where n is between 369 and 419 inclusive, are useful as substitutes for albumin in the treatment of burns and shock in humans, the clearance of undesirable compounds, (such as bilirubin) from human blood, in laboratory growth media and in HSA assays. The polypeptides may be produced by recombinant DNA techniques, especially in yeast.

REFERENCES:
Lawn, et al., Nucl. Acids Res. 9, 6102-6114 (1981).
Brown & Schockley, in "Lipid-Protein Interactions", 1, Ed. P. C. Jost (1982).
Galliano, et al., J. Biol. Chem. 261(9), 4283-4287 (1986).
Takahashi, et al., P.N.A.S., 84, 4413-4417 (1987).
Doyen, et al., J. Biol. Chem 257(6), 2770-2774 (1982).
Geisow & Beaven, Biochem. J. 163, 477-484 (1977).

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