S. lavendofoliae DKRS cell culture producing anti-tumor aclacino

Details S. lavendofoliae DKRS cell culture producing anti-tumor aclacino S. lavendofoliae DKRS cell culture producing anti-tumor aclacino

1994-02-04

1995-11-21

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 78, 435886, 536 64, C07H 1704, C07H 15244, C12N 120

Patent

active

054686377

ABSTRACT:
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.

REFERENCES:
patent: 3988315 (1976-10-01), Umezawa et al.
ATCC Catalogue "Bacteria & Bacteriophages" 18th ed. Editors Gherna et al. Pub 1992 p. 335.

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