(S)-4-amino-hepta-5,6-dienoic acid and intermediates therof

Details (S)-4-amino-hepta-5,6-dienoic acid and intermediates therof (S)-4-amino-hepta-5,6-dienoic acid and intermediates therof

1997-01-09

1998-05-26

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548545, 548547, 548551, 548556, 548574, 548578, C07D20746

Patent

active

057567620

ABSTRACT:
The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and a process for preparing an intermediate thereof.

REFERENCES:
Holmes et al, J. Chem. Soc. Perkin Trans., pp. 3301-3306, (1991).
Holmes et al, J. Chem. Soc. Perkin Trans., pp. 3307-3313, (1991).
Doedens, et al, J. Org. Chem, 53, 685-890, (1988).
Fischer, et al, Tetrahedron, vol. 42, No. 7, pp. 2063-2074, (1986).
Lindgren et al., Acta Pharm. Suec., vol. 12, No. 5-6, pp. 503-506, (1975).
"Allenic Amino Acids. 1. Synthesis of .gamma.-Allenic GABA by a Novel Aza-Cope Rearrangement" A.L. Castelhano and A. Krantz, J. Amer. Chem. Soc. 1984, 106, pp. 1877-1879.

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