Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Protein – amino acid – or yeast containing
Reexamination Certificate
1999-03-03
2001-05-29
Sayala, Chhaya D. (Department: 1761)
Food or edible material: processes, compositions, and products
Products per se, or processes of preparing or treating...
Protein, amino acid, or yeast containing
C426S807000
Reexamination Certificate
active
06238727
ABSTRACT:
TECHNICAL FIELD
When biologically active substances such as amino acids and vitamins are orally administered directly into ruminants such as cow and sheep, most of these substances are decomposed by microorganisms in the rumen, and are, therefore, not utilized effectively. Accordingly, rumen bypass preparations for use in ruminants with which these biologically active substances are protected from the decomposition by microorganisms in the rumen but digested and absorbed in the abomasum and lower digestive organs are important in the field of ruminant feed, nutrients and drugs, etc.
In this respect, it is considered that biologically active substances should be protected with a material for protecting the same from gastric juice (its pH being in a neutral region) in the rumen of ruminants while allowing the same to dissolve in the abomasum (its pH being in an acidic region) and lower digestive organs.
The present invention relates to the protection of biologically active substances based on this concept. That is, the present invention relates to a ruminant feed additive composition and a process for producing the same. More specifically, the ruminant feed additive composition of the present invention contains physiologically active substances, namely, amino acids, especially lysine, and can easily be produced by an extrusion-granulating method.
DESCRIPTION OF THE BACKGROUND ART
With respect to the ruminant feed additive composition for the biologically active substances based on the concept described above (rumen bypass preparations), a great many proposals have been made.
That is, as a method for obtaining a ruminant feed additive to solve such problems, there is disclosed in JP-B-59-10780 and JP-A-60-168351, e.g., a method in which a biologically active substance is dispersed in a matrix containing a protective substance such as fats and oils and the dispersion is granulated. However, since a biologically active substance present on or in the vicinity of the surface of a particulate product is easily decomposed, the effect is reduced especially when the residence time in the rumen is long. Further, there is disclosed in JP-A-54-46823 and JP-A-63-317053 another method in which a core containing a biologically active substance is coated with a hydrophobic material such as fats and oils, etc. or an acid-sensitive material such as a basic high-molecular substance, etc. However, in case of a formula or compound feed, in particular, such coating is at times destroyed owing to the influence of other ingredient(s). Thus, the method can not be said to be an all-purpose method. Furthermore, there is disclosed in JP-A-9-172979 an animal feed additive composition containing a phosphoric acid amino acid composite salt insoluble in a neutral or alkaline aqueous solution but soluble in an acidic aqueous solution and an antacid. Such animal feed active composition is, however, difficult to granulate in such way that the said additive composition gets easy to handle and can be simply and easily added to an animal feed.
Meanwhile, with respect to a method for producing an active element particulate material through extrusion, Japanese Patent No. 2558023 (corresponding to JP-A-4-230318) discloses a method for granulating a nutritively or therapeutically active element composition containing the active element in an amount of more than 75% by weight, which comprises extruding the active element mass in the presence of a meltable binder (melt route method). Nevertheless, this method is a substitute for a method in which a mixture wet with the addition of water is extruded (U.S. Pat. No. 4,181,710, wet route method), and it does not provide a method for extrusion-granulating a mixture having a fixed water content.
Accordingly, a ruminant feed additive composition of which the physiologically active substance is not decomposed in the rumen and is effectively utilized in the abomasum and lower digestive organs, that is, where resistance to rumen juice and dissolution in the abomasum are well-balanced, and which is easy to granulate, has not been obtained. That is, conventional rumen bypass preparations are problematic in their own biochemical and physical properties or their production method. Thus, the further improvement thereof has been in high demand.
(Problems That the Invention Is To Solve)
Accordingly, it is an object of the present invention to provide a ruminant feed additive composition where, when a ruminant feed additive contains a physiologically active substance, the physiologically active substance is fully protected in the rumen of a ruminant and rapidly dissolved in the abomasum, and which can easily be granulated by an extrusion-granulating method and the like, and a process for producing the same. In other words, in the background of the background art just described in the previous section, the present invention aims to provide a ruminant feed additive composition product of which the biochemical and physical properties (protection in the rumen and dissolution in the abomasum) are excellent, and an excellent process for producing a ruminant feed additive composition by which such a ruminant feed additive composition product can easily be produced.
(Means For Solving the Problems)
The present inventors have assiduously conducted investigations to achieve the object, and have consequently found that the object can be achieved by using, for a feed additive, lysine magnesium phosphate and magnesium oxide together, and further having a fixed water content. A first invention has been completed on the basis of these findings.
That is, the first invention relates to a ruminant feed additive composition containing (A) lysine magnesium phosphate, (B) magnesium oxide, (C) a binder and (D) water, the water content being between 5 and 15% by weight.
The invention further relates to a process for producing such a ruminant feed additive composition, which comprises (1) a step of mixing lysine magnesium phosphate, magnesium oxide and a binder, (2) a step of feeding water or steam (or water vapor) to the mixture, and (3) a step of extrusion-granulating the resulting hydrous (or water-containing) mixture.
The present inventors have assiduously conducted further investigations to achieve the object, and have consequently found that, in a method of producing a ruminant feed additive composition comprising coating a core (particle) containing a biologically active substance, for example, lysine magnesium phosphate, with a coating agent such as fats and oils, when said core is prepared by drying a particle formed by extrusion-granulating such a biologically active substance, a meltable binder, and water and, in addition, magnesium oxide as starting materials, under such conditions that the water contained therein is released as water vapor to render porous the structure of the particle and at the same time the resultant pores are filled with the molten binder present, and then the surface of the thus-formed dry particle (core) is coated with a coating agent, the object can easily be achieved. A second invention has been completed on the basis of these findings.
That is, the second invention relates to a process for producing a ruminant feed additive composition, which comprises uniformly mixing (a) lysine magnesium phosphate, (b) magnesium oxide, (c) a meltable binder and (d) water (in as small an amount as possible) required for extrusion granulation, subjecting this mixture to extrusion granulation at a temperature at which the meltable binder is not deteriorated, drying the resulting particle under such conditions that the water contained therein is released as water vapor to render porous the structure of the particle and at the same time the resulting resulting pores are filled with the molten binder present, and then coating the surface of the dry particle with a coating agent, as well as a process for producing a ruminant feed additive composition, which comprises uniformly mixing (a) lysine magnesium phosphate, (b) magnesium oxide and (c) a meltable binder, feeding this uniform powder mixtur
Kato Toshihisa
Kitamura Nobuyoshi
Mori Ken-ichi
Oshimura Masahiko
Takemoto Tadashi
Ajinomoto Co. Inc.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Sayala Chhaya D.
LandOfFree
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