Rooperol and its derivates

Details Rooperol and its derivates Rooperol and its derivates

1985-06-04

1987-02-17

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

536 41, 536 181, 562465, 568308, 568325, 568613, 568646, 568648, 568650, 568652, 568715, 568807, 568813, 568849, 568857, 585505, C07C 3921, C07C 3304, C07C 4320, C07C 5976

Patent

active

046440852

ABSTRACT:
The invention relates to a new anti-cancer chemical compound which has been called rooperol and certain derivatives thereof of the general formula ##STR1## in which A is chosen from the group including a phenyl group, a substituted phenyl group and --CH.sub.2 --O--R.sup.5 where R.sup.5 =H, an alkyl (C.sub.1 -C.sub.5), aralkyl or acyl substituent; R.sup.1 and R.sup.2 are chosen from substituents including H for both or singly if one of them is --OH, --NH.sub.2, --SH, ##STR2## or taken together R.sup.1 and R.sup.2 are =0; R.sup.3 is H or ##STR3## where R.sup.6 is an alkyl group (C.sub.1 -C.sub.7); either of R.sup.4 or B are chosen from substituents including H, ##STR4## a phenyl group, substituted phenyl group or a furyl group.

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Drewes et al, "Chemical Abstracts" vol. 100 (1984) pp. 61782m and 86054p.
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U.S. Appln. #729,683, filed 5/1985.

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