Role of p62 in aging-related disease

Details Role of p62 in aging-related disease Role of p62 in aging-related disease

2003-05-14

2008-10-14

Chen, Shin-Lin (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C800S014000, C424S093210, C435S320100, C435S455000

Reexamination Certificate

active

07435872

ABSTRACT:
The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

REFERENCES:
patent: 5962224 (1999-10-01), Shin et al.
patent: 6291645 (2001-09-01), Shin et al.
patent: WO 03/012134 (2003-02-01), None
Olsen et al., 2000, GABA in the Nervous System: the View at Fifty Years/ Editors, David I. Martin, Richard W. Olsen, Chapter 6: Function of GABA Receptors, Insight from Mutant and Knockout Mice, p. 81-95, Lippincott Williams & Wilkins, Philadelphia.
Rescher et al., 2004, Journal of Cell Science, vol. 117, p. 2631-2639.
Mogil et al., 1999, Pain, vol. 80, pp. 67-82.
Sigmund, C., Jun. 2000, Arterioscler. Thromb. Vasc. Biol., p. 1425-1429.
Leonard et al., 1995, Immunological Reviews, vol. 148, pp. 97-114.
Wolfer et al., 2002, Trends in Neurosciences, vol. 25, No. 7, p. 336-340.
Geetha, Thangiah et al. “Structural and functional properties of the ubiquitin binding protein p62”, FEBS Letters 512 (2002) pp. 19-24.
Zatloukal, Kurt et al. “p62 is a common component of cytoplasmic inclusions in protein aggregation diseases”, American Journal of Pathology 160(1) (Jan. 2002) pp. 255-263.
Shin and Moon, “P62 sequesters multi-ubiquitin conjugated proteins from the cytoplasm,” Molecular Biology of the Cell, 10: 297a (1999).
Geetha and Wooten, “Association of the Atypical Protein Kinase C-interacting Protein p62/ZIP with Nerve Growth Factor Receptor TrkA Regulates Receptor Trafficking and Erk5 Signaling,” Journal of Biological Chemistry, 278(7): 4730-4739 (2003).

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