Rifamycins and method for their preparation

Details Rifamycins and method for their preparation Rifamycins and method for their preparation

1977-07-01

1979-12-18

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D49808

Patent

active

041794397

ABSTRACT:
The invention is concerned to new hydrazones and oximes of 3-formylrifamycin SV.
The procedure of rifamycin derivatives preparation consists of condensation of 3-formylrifamycin SV with reactants suitable for carbonylic group, using solvents alone or in mixture, as reaction medium, in which are attained high concentrations of reactants, and from which the reaction products can be easily isolated, by possibly a partial concentration and/or water addition, when they separate under crystalline form.
The solvents and the working conditions selected, e.g. the reactant for carbonylic group in excess up to 0.25 mol, reduce the danger of inflammability, simplify the operations, decrease the degradations level and lead to pure products, so that their recrystallization is no longer necessary.
Among the obtained rifamycins, may be selected products showing reduced liver toxicity, active against mycobacteria rifamycin-resistant forms or specific antiviral-oncogene, immunosuppressive, antileukemic (in man) etc., activity utilizable in clinical use.

REFERENCES:
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3862934 (1975-01-01), Cricchio et al.
patent: 3865812 (1975-02-01), Cricchio et al.
patent: 3933800 (1976-01-01), Cricchio et al.
patent: 3963705 (1976-06-01), Marsili et al.
patent: 4005076 (1977-01-01), Cricchio et al.

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