Ribozyme cleavage of HIV-I RNA

Details Ribozyme cleavage of HIV-I RNA Ribozyme cleavage of HIV-I RNA

1989-06-21

1992-09-01

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424 946, 514934, C07H 1700, A61K 3754

Patent

active

051440199

ABSTRACT:
Stable, catalytic efficient ribozymes useful, inter alia, to cleave HIV-I RNA or any other viral or endogenous cellular RNA, in vitro and in vivo, cells transformed with such ribozymes and the use of such ribozymes and cells for anti-AIDs therapy are disclosed.

REFERENCES:
J. Perreault, et al., Nature, 344:565-567, 1990.
Chem. Abst. 110(21):187321k, 1989; 112(7):51284; 1990; 112(7):52942j, 1990; 112(13):1135276, 1990.
Chem. Abstract, 112(19):175480q, 1990.
F. Cameron, et al PNAS, 86:9139-9143, 1989.

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