Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-11-25
1999-08-03
Minnifield, Nita
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241841, 4242001, 4242441, 4242371, 530324, C07K 100, C07K 1400, C07K 1700, A61K 3909
Patent
active
059327014
ABSTRACT:
The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
REFERENCES:
Richter, et. al., "Biosynthesis of Riboflavin: Cloning, Sequencing, Mapping, and Expression of the Gene Coding for GTP Cyclohydrolase II in Escherichia coli." Journal of Bacteriology, vol. 175, No. 13, pp. 4045-4051, Jul., 1993.
Foor, et al., "GTP Cyclohydrolase II from Escherichia coli." Methods in Enzymology, vol. 66, pp. 303-307.
Fuller, et. al., "A Riboflavin Auxotroph of Actinobacillus pleuropneumoniae Is Attenuated in Swine." Infection and Immunity, vol. 64, No. 11, pp. 4659-4664, Nov. 1996.
Lui et al Micro bial Pathogenesis 22: 227-234, 1997.
Black Michael Terence
Fedon Jason Craig
Hodgson John Edward
Knowles David Justin Charles
Kosmatka Anna Lisa
Gimmi Edward R.
Jackson Arthur E.
King William T.
Minnifield Nita
SmithKline Beecham Corporation
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