Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1996-10-03
1999-08-03
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
4351723, 435 696, 435236, 424 932, 4242071, C12N 700, C12N 1500, C12P 2104, A01N 6300
Patent
active
059324678
ABSTRACT:
Cells producing recombinant retroviral particles are provided. The cells contain a first vector having a coding region encoding retroviral LTRs and a packaging signal under the control of an expression control system, a tRNA binding site located upstream from the packaging signal and origin of second strand DNA synthesis located downstream from the packaging signal. The cells also contain a second vector having a coding region encoding retroviral capsid proteins gag and pol under the control of an expression control system and a third vector having a coding region encoding a simian type D retrovirus envelope glycoprotein under the control of an expression control system.
REFERENCES:
Koo H. et al., Pseudotyped REV/SRV retroviruses reveal restrictions to infection and host range within members of the same receptor interference group, Virology 205:345-351, 1994.
Bosselman R. et al., Replication-defective chimeric helper proviruses and factors affecting generation of competent virus:Expression of Molony Murine Leukemia Virus structural genes via the metallothionein promoter, Mol. Cell. Biol. 7(5):1797-1806, May 1987.
Miller A. et al. Improved retroviral vectors for gene transfer and expression, Biotechniques 7(9):980-990, 1989.
Fan H. Murine Leukemia Viruses, in Encyclopedia of Virology v2, ed. Webster R. and Granoff A., Academic Press:883-890, 1994.
Moolton, Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transferred by Retroviral Vectors, 1990, J Natl Cancer Inst 82: 297-300.
Rhee, Preassembled Capsids of Type D Retroviruses Contain a Signal Sufficient for Targeting Specifically to the Plasma Membrane, 1990, J Virol 64:3844-52.
Jensen, Isolation and Propagation of a Virus from a Spontaneous mammary Carcinoma of a Rhesus Monkey, 1970, Cancer Res 30:2388-93.
Wang, Cell-Surface Receptor for Ecotropic Murine Retroviruses is a Basic Amino-acid Transporter, 1991, Nature 352:729-31.
Rosen, Gene Therapy for Cancer, 1992, JAMA 268:2416-19.
Wolff, Grafting Fibroblasts Genetically Modified to Produce L-dopa in a Rat Model of Parkinson Disease, 1989, Proc Natl Acad Sci 86:9011-14.
Kasid, Human Gene Transfer: Characterization of Human Tumor-Infiltrating Lymphocytes as Vehicles for Retroviral-mediated Gene Transfer in Man, 1990, Proc Natl Acad Sci 87:473-477.
Rosenberg, Immunotherapy and Gene Therapy of Cancer, 1991, Cancer Res (Supp) 51:4074s-79s.
Anderson, Human Gene Therapy, 1992, Science 256:808-13.
Levine, Towards Improved Cancer Diagnosis and Treatment Founded on Current Developments in the Basic Sciences: Options for Intensified European Efforts, 1991, Eur J Cancer 27:936-39.
Culver, In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors, 1992, Science 256:1550-52.
Rhodes, Inhibition of Heterologous Strains of HIV by Antisense RNA, 1991, AIDS 5:145-51.
Von Ruden, Inhibition of Human T-Cell Leukemia Virus Type I Replication in Primary Human T Cells that Express Antisense RNA, 1989, J Virol 63:677-82.
Giovannangeli, Single-Stranded DNA as a Target for Triple-Helix Formation, 1991, J Am Chem Soc: 113:7775-77.
Bosselman, Replication-Defective Chimeric Helper Proviruses and Factors Affecting Generation of Competent Virus: Expression of Moloney Murine Leukemia Virus Structural Genes via the Metallothionein Promoter, 1987, Mol and Cell Biol 7:1797-1806.
Markowitz, A Safe Packaging Line for Gene Transfer: Separating Viral Genes on Two Different Plasmids, 1988, J Virol 62:1120-24.
Dougherty, New Retrovirus Helper Cells with Almost No Nucleotide Sequence Homology to Retrovirus Vectors, 1989, J Virol 63:3209-12.
Miller, Improved Retroviral Vectors for Gene Transfer and Expression, 1989, BioTechniques 7:980-90.
Kim, Transport of Cationic Amino Acids by the Mouse Ecotropic Retrovirus Receptor, 1991, Nature 352:725-28.
Oldfield, Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir, 1993, Human Gene Therapy 4:39-69.
Neda, Chemical Modification of an Ecotropic Murine leukemia Virus Results in Redirection of its Target Cell specificity, 1991, J Biol Chem 266:14143-46.
Kasahara, Tissue-Specific Targeting of Retroviral Vectors Through Ligand-Receptor Interactions, 1994, Science 266:1373-76.
Deminie, Functional Exchange of an Oncoretrovirus and a Lentivirus Matrix Protein, 1994, J Virol 68:4442-49.
Miller, Targeted Vectors for Gene Therapy, 1995, FASEB J 9:190-99.
Von Kalle, Increased Gene Transfer into human Hematopoietic Progenitor Cells by Extended In Vitro Exposure to a Pseudotyped Retroviral Vector, 1994, Blood 84:2890-97.
Gardner, Chapter 5: The Simian Retroviruses SIV and SRV in The Retroviridae, vol. 3, 1994, Jay A Levy ed, Plenum Press, New York.
Barker, Molecular Cloning of the Mason-Pfizer Moneky Virus Genome: Biological Characterization of Genome Length Clones and Molecular Comparisons to Other Retroviruses, 1986, Virology 153:201-14.
Sonigo, Nucleotide Sequence of Mason-Pfizer Monkey Virus: An Imumunosuppressive D-Type Retrovirus, 1986, Cell 45:375-85.
Power, Nucleotide Sequence of SRV-1, a Type D Acquired Immune Deficiency Syndrome Retrovirus, 1986, Science 231:1567-72.
Marracci, Simian AIDS Type D Serogroup 2 Retrovirus: Isolation of an Infectious Molecular Clone and Sequence Analyses of its Envelope Glycoprotein Gene and 3' Long Terminal Repeat, 1995, J Virol 69:2621-28.
Sommerfelt, Expression of Simian Type D Retroviral (Mason-Pfizer Monkey Virus) Capsids in Insect Cells Using Recombinant Baculovirus, 1993, Virology 192:298-306.
Koo, Pseudotyped REV/SRV Retroviruses Reveal Restrictions to Infection and Host Range within Members of the Same Receptor Interference Group, 1994, Virology 205:345-51.
Khan Mohammad Ayub
Murphy John E.
Ralston Robert O.
Achutamurthy Ponnathapura
Blackburn Robert P.
Chiron Corporation
Cserr Luann
Kruse Norman J.
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