Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-11-15
1996-01-09
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142352, 514314, 514482, 514588, 514596, 544128, 546169, 560 27, 560 29, 560125, 564 47, 564 56, 564 57, 564 59, A61K 3147, A61K 3117, C07D21548
Patent
active
054829470
ABSTRACT:
Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5132400 (1992-07-01), Gammill et al.
patent: 5151438 (1992-09-01), Sham et al.
Plattner et al., J. Med. Chem., 31, 2277-2288 (1988).
Bolis et al., J. Med. Chem., 30, 1729-1737 (1987).
Haber et al., J. Cardiovascular Pharm. 554-558 (1987).
Burger, Medicinal Chemistry, pp. 565-571, 578-581, 600-601 (1960).
Denkelwalter et al., Progress in Drug Research pp. 510-512 (1966).
Rich et al, Peptide Inhibitors of Proteases, 511-520 (1990).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).
Roberts et al, "Rational Design of Peptide-based Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al, "Design activity, and 2.8.ANG. Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Pearl et al, "Sequence specificity of retroviral proteases" Nature, 328, (1987).
Martin, Drugs of the Future, 16(3), 210-212 (1991).
Meek et al, Letter To Nature, 343, 90-92 (1990).
McQuade et al, Science, 247, 454-456 (1990).
Clare Michael
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel P.
Heintz Robert M.
Dentz Bernard
Ungemach Frank s.
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