Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-07
2000-10-31
Clark, Deborah J.
Chemistry: molecular biology and microbiology
Vector, per se
435456, 4352351, 514 44, 424 932, C12N 1563, C12N 1585, C12N 1582, A61K 4800
Patent
active
061401110
ABSTRACT:
Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. These retroviral vectors are especially suited for use in certain packaging cell lines.
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Cohen Lawrence K.
Guild Brad
Mulligan Richard C.
Rafield Lori F.
Riviere Isabelle
Cell Genesys Inc.
Clark Deborah J.
Whitehead Institute for Biomedical Research
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