Retinoid formulations in porous microspheres for reduced irritat

Details Retinoid formulations in porous microspheres for reduced irritat Retinoid formulations in porous microspheres for reduced irritat

1995-12-29

1998-12-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 7802, 424 7803, 514844, 514938, A61K 700, A61K 702

Patent

active

058515380

ABSTRACT:
Retinoids for topical skin application are formulated as impregnants in porous microspheres. Thus formulated, the retinoids display a surprisingly high level of stability and low degree of skin irritation.

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B. Rossler et al., "Effect of collagen microparticles on the stability of retinol and its absorption into hairless mouse skin in vitro", Pharmazie, 49(2/3), 175-179 (1994).
Chem. Abs., 121(6), 65491x (1994); abstract of S. Torrado et al., "Microencapsulation of vitamin A", An. R. Acad. Farm., 59(1), 109-119 (1994).

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