Retinoid composition having enhanced bioavailability and percuta

Details Retinoid composition having enhanced bioavailability and percuta Retinoid composition having enhanced bioavailability and percuta

1986-12-15

1988-02-23

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

424DIG5, 514859, 514863, A61K 748, A61K 3120

Patent

active

047270888

ABSTRACT:
A new and improved topically applied pharmaceutical preparation for the treatment of acne and an improved vehicle for delivering the active ingredients thereof to the human skin in a manner whereby the bioavailability and percutaneous absorption of the active ingredient is remarkably enhanced. The vehicle comprises a volatile silicone, a fatty alcohol having from 12-22 carbon atoms, retinoids selected from the group consisting of tretinoin (all-trans retinoic acid) and isotretinoin (13-cis retinoic acid); and such preservatives or emulsifying agents as may be warranted.

REFERENCES:
patent: 4022913 (1977-05-01), Newmark
patent: 4603146 (1986-07-01), Kligman

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