Repair of larynx, trachea, and other fibrocartilaginous tissues

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

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C424S093700, C424S422000, C424S426000, C435S007100, C435S180000, C435S177000, C514S002600, C514S012200

Reexamination Certificate

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06958149

ABSTRACT:
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

REFERENCES:
patent: WO 95/16035 (1995-06-01), None
patent: WO 95/33502 (1995-12-01), None
patent: WO 96/14335 (1996-05-01), None
patent: WO 96/39170 (1996-12-01), None
patent: WO 98/31788 (1998-07-01), None
Cui, P. C. et al., “Repair of thyroid cartilage defect with bone morphogenetic protein,”Annals of Otology, Rhinology and Laryngology, 106(4), pp. 326-328 (1997).
Majstorovic, L. et al., “Biological repair of thyroid cartilage defects by osteogenic protein-1 (bone morphogenetic proteins-7) in dog,”Bone(Abstracts), 24(4), p. 419, abstract No. 42 (1999).
Vukicevic, S. et al., “Thyroid and articular cartilage repair in dog and sheep by OP-1,”Bone(Abstracts), 24(4), p. 423, abstract No. 57 (1999).

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