Renin inhibitors IV

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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Details

514 19, 530330, 530331, 544 86, 544162, 548561, 558 5, 560 28, 560 39, 564 28, 564104, 564108, 564153, A61K 3702, C07K 500

Patent

active

050249940

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.

REFERENCES:
patent: 4609641 (1986-09-01), Evans et al.
Haber et al., J. Cardiovasc. Pharmacol., 1987, 10(Suppl. 7):554-558.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress in Drug Research, vol. 10, 1966, pp. 510-512.
Plattner et al., J. Med. Chem., 31(12), 1988, pp. 2277-2288.

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