Renin inhibiting compounds

Details Renin inhibiting compounds Renin inhibiting compounds

1992-05-04

1993-10-05

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, 544 60, 544124, 544132, 544139, 544140, 544141, 544143, 544284, 544324, 544353, 544370, 548150, 548165, 548190, 548218, 5482664, 5483381, 5483385, 930 21, 930 24, 546 84, 546153, 546276, 546241, 546101, 546104, 546109, 546208, C07K 510, C07K 508, C07D23514, A61K 3702

Patent

active

052505170

ABSTRACT:
Compounds which are amino acid derivatives and have the formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl or imidazol-4-yl, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.

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patent: 4713445 (1987-12-01), Szelke et al.
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patent: 5140011 (1992-08-01), Branca et al.
Szelke, et al. Chemical Abstracts, vol. 101, 1984, Abstract 86219s.
Biochemical Soc. Trans. 10, 164 (1982).
Science, 217, 121 (1982).
Biochem. & Biophys. Res. Commun. 146(3), 959 (1987).

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