Renal growth promoter and process for the production of the same

Details Renal growth promoter and process for the production of the same Renal growth promoter and process for the production of the same

1988-12-01

1991-10-08

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

520397, 520398, 520399, C07K 720, A61K 3724

Patent

active

050555545

ABSTRACT:
The present invention relates to a renal growth promoter based on the finding that luteinizing hormone or an isoform thereof has an effect of promoting renal growth.
It was previnsly unknown that luteinizing hormone or an isoform thereof has an effect of promoting renal growth.
With the present invention, it is expected that kidneys suffering from a decreased in the number of renal cells or a lowering in the renal function may be activated by administering luteinizing hormone or an isoform thereof.

REFERENCES:
patent: 4383035 (1983-05-01), Sugimoto
Nomura, K. et al., Proc. Natl. Acad. Sci., 79: 6675-6679, Nov. 1982.
Stenesh, Dictionary of Biochemistry, p. 168, 1975.
Stedman, Stedman's Medical Dictionary, 24th Ed., p. 730, 1982.
Grant, Hackh's Chemical Dictionary, 4th Ed., p. 361, 1969.
Nomura et al., Endocrinology, 123 (2): 700-711, Aug. 1988.
Nomura et al., Endocrinology, 124(2): 712-719, 1989.
Nomura et al., Nephron, 39: 255-260, 1985.
Nomura, K. et al., Endocrinology, 116(2), p. 616-621, 1985.
Ward, D. et al., Int. J. Peptide Protein Res., 27, pp. 70-78, 1986.
Yano, M. Acta Abst. Gynaec, Jpn. 37(5): pp. 703-712, 1985.
Sairam, M. R. (1980), "Deglycosylation of Ovine Pituitary Lutropin Subunits: Effects on Subunit Interaction and Hormone Activity", Archives of Biochemistry and Biophysics, vol. 204, No. 1, Oct., pp. 199-206.
Bahl et al. (1980), "A Novel Carbohydrate Structure in Bovine and Ovine Luteinizing Hormones", Biochemical and Biophysical Research Communications, vol. 96, No. 3, Oct. 16, pp. 1192-1199.
Austin III et al., Nephron, "Humoral Regulation of Renal Growth", vol. 27, pp. 163-170.
Nomura et al., Chemical Abstracts, vol. 110, No. 13, Mar. 27, 1989, p. 89, Abstract 108335s.
Matteri, R. L. et al., "Characterization of Equine Luteinizing Hormone by Chromatofusing", Biology of Reproduction, 36, 261-269 (1987).
Baldwin, David M. et al., "An In Vitro Study of LH Release, Synthesis and Heterogeneity in Pituitaries from Proestrous and Short-Term Ovariectomized Rats", Biology of Reproduction 34, 304-315 (1986).
Johnston, Robyn C. et al., "High-Performance Liquid Chromatography of Amino Acids, Peptides and Proteins; LXXXV. Separation of Isoforms of the Glycoprotein Hormones from Human Pituitary Extracts," Journal of Chromatography 397, 389-398 (1987).
Strickland, Thomas W. et al., "Contribution of Subunits to the Function of Luteinizing Hormone/Human Chorionic Gonadotropin Recombinants", Endocrinology 109(6), 1933-1942 (1981).
Chemical Abstracts, vol. 102, No. 11, Abstract No. 90348W (Chem. Abstr. 102:90348W), Mar. 18, 1985 (18.03.85), Columbus, Ohio, Nomura et al.
Nippon Rinsho, 44 (1), Separate Issue, 84-88 (Jan. 1, 1986).
M. Yano, J. Jap. Tocol. Gynecol., 37 (5), 703-712 (1985).

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