Regulation of target protein activity through modifier proteins

Details Regulation of target protein activity through modifier proteins Regulation of target protein activity through modifier proteins

2007-11-06

2007-11-06

Achutamurthy, P. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S183000, C435S004000, C435S006120, C435S024000, C514S789000, C536S023200, C536S023700, C536S023500

Reexamination Certificate

active

10047253

ABSTRACT:
The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.

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