Regulating gene expression using retinoids with Ch.sub.2 OH or r

Details Regulating gene expression using retinoids with Ch.sub.2 OH or r Regulating gene expression using retinoids with Ch.sub.2 OH or r

1995-01-11

1998-07-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514729, 514723, A61K 31115, A61K 31045, A61K 3108

Patent

active

057863911

ABSTRACT:
For the first time, certain retinoids with a side chain terminal CH.sub.2 OH group or ester or ether thereof or aldehyde rather than a side chain terminal COOH group and substitution at the 4-position have been indicated to bind to nuclear receptors and to be biologically active in inducing cell differentiation of normal and tumor cells. These compounds activate gene expression through binding to nuclear receptor proteins. These compounds induce differentiation in normal and cancer cells and are useful for treating leukemias, and lymphomas, squamous cell carcinomas, deep (cystic) acne, psoriasis and photodamaged or aging skin. These compounds have stability and in vitro half-life advantages over and solubility differences from all-trans-retinoic acid and activity advantages over 13-cis retinoic acid.

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