Reduction or prevention of skin irritation by drugs

Details Reduction or prevention of skin irritation by drugs Reduction or prevention of skin irritation by drugs

1990-07-06

1992-07-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424448, 424449, A61K 3722

Patent

active

051301393

ABSTRACT:
The present invention provides a method of reducing or preventing skin irritation of a weak base drug by inhibiting the accumulation of the drug in the lysosomes. The drug is irritating to humans, i.e., the drug is susceptible to inducing skin or mucosa irritation in a human when the drug is transdermally administered to the human at a therapeutically effective rate. Irritation reduction or prevention is induced by coadministering to the skin or mucosa of the human:

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