Reducible compounds which provide leuco dyes for analytical comp

Details Reducible compounds which provide leuco dyes for analytical comp Reducible compounds which provide leuco dyes for analytical comp

1988-07-05

1992-04-28

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 25, 435 26, 435 29, 435 34, C12Q 126, C12Q 100

Patent

active

051089033

ABSTRACT:
Certain reducible compounds are useful in analytical compositions, elements and methods, for example for the detection of bacterial cells. These compounds comprise a moiety which provides a leuco dye upon reduction. This lecuo dye can then be oxidized with additional molecules of reducible compound in order to provide a detectable dye. Thus, these reducible compounds are considered bioamplifiers from which a multiplicity of dye molecules can be provided from a single reducible compound molecule. Structurally, the reducible compounds are quinones having suitable substituents which promote varying amounts of leuco dye release at physiological pH.

REFERENCES:
patent: 4144306 (1979-03-01), Figueras
patent: 4409323 (1983-10-01), Sato et al.
patent: 4610961 (1986-09-01), Guardino et al.
patent: 4840884 (1989-06-01), Mooberry et al.
patent: 4857271 (1989-08-01), Belly et al.

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