Recombinant polynucleotides encoding pro-geldanamycin...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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C435S193000, C435S069700, C435S252350, C435S320100, C536S023200

Reexamination Certificate

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10461194

ABSTRACT:
The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.

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NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 154)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 155)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 156)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 157)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 158)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 159)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 160)(May 1, 2006).
NCBI BLASTP 2.2.14 Database search results, “sequences producing significant alignments” to query sequence (SEQ ID No. 161)(May 1, 2006).
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