Recombinant mutants for inducing specific immune responses

Details Recombinant mutants for inducing specific immune responses Recombinant mutants for inducing specific immune responses

1994-11-07

1996-04-02

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

4241841, 4241851, 4241901, 4242011, 4242531, 4242541, 4242341, 435 693, 514 2, 530350, 530825, 536 237, 536 234, A61K 3910, A61K 39295, C07K 14235, C07K 1700

Patent

active

055038298

ABSTRACT:
A recombinant plasmid comprises the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella, adenylate cyclase in a transformed host cell. A recombinant DNA molecule can comprise the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. In addition, a recombinant Bordetella adenylate cyclase comprises a heterologous epitope at a permissive site. Methods of inducing a specific B cell, helper T cell, and CTL cell immune response are provided.

REFERENCES:
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