Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-21
1995-12-05
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352402, 4352523, 4352523, 43525411, 4353201, 43525233, 536 231, C12N 1509, C12N 1563, C12P 2102
Patent
active
054728568
ABSTRACT:
The present invention provides novel nucleotide and amino acid sequences for human thymopoietin .alpha., .beta., and .gamma., methods of recombinantly expressing same, and diagnostic and therapeutic uses thereof.
REFERENCES:
patent: 4002740 (1977-01-01), Goldstein et al.
patent: 4077949 (1978-03-01), Goldstein
patent: 4120951 (1978-10-01), Goldstein
patent: 4190646 (1980-02-01), Goldstein et al.
patent: 4745051 (1988-05-01), Smith et al.
patent: 4923964 (1990-05-01), Goldstein et al.
Sambrook et al. Molecular Cloning, A Lab. Manual, vol. 3, chip 16, pp. 16.2-16.31 Cold Spring Harbor Lab. Press, 1989.
C. Harris et al, "Three Distinct Human Thymopoietins are Derived from Alternatively Spliced mRNAs", Proc. Natl. Acad. Sci. USA, 91(14):6283-6287 (Jul. 1994).
C. Harris et al, "Multiple Distinct Human Thymopoietins are Derived from Alternatively Spliced mRNAs", Mol. Biol. of the Cell, 4(Suppl.):453a, Abstract No. 2632 (Oct. 1993).
K. Bolla et al, "Prevention of Recurrences in Frequently Relapsing Herpes Labialis with Thymopentin", Surv. Immunol. Res., 4(1):37-47 (1985).
E. Sundal and K. Bolla, "Therapy with Thymopentin: A Clinical Overview", Immune Regulation by Characterized Polypeptides, ed. Alan R. Liss, Inc., pp. 121-136 (1987).
G. Goldstein et al, "Isolation of Bovine Thymin: A Polypeptide Hormone of the Thymus", Nature, 247(5435):11-14 (Jan. 4, 1974) [Goldstein I].
G. Goldstein et al, "A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin", Science, 204:1309-1310 (Jun. 22, 1979).
M. Scheid et al, "The Generation and Regulation of Lymphocyte Populations, Evidence from Differentiative Induction Systems in vitro", J. Exp. Med., 147:1727-1743 (Jun. 1, 1978) [Scheid I].
M. Scheid et al, "Differentiation of T Cells in Nude Mice", Science, 190:1211-1213 (Dec. 19, 1975) [Scheid II].
K. Venkatasubramanian et al, "Binding of Thymopoietin to the Acetylcholine Receptor", Proc. Natl. Acad. Sci. USA, 83;3171-3174 (May 1986).
T. Abiko et al, "Syntheses and Effects of a Thymopoietin II Fragment and its Analogs on the Impaired T-Cell Transformation in a Patient with Common Variable Immunodeficiency", J. Appl. Biochem., 7:408-422 (publ. Dec. 1985; mailing date Mar. 11, 1986).
D. Schlesinger et al, "The Amino Acid Sequence of Thymopoietin II", Cell, 5:361-365 (Aug. 1975).
T. Audhya et al, "Complete Amino Acid Sequences of Bovine Thymopoietins I, II, and III: Closely Homologous Polypeptides", Biochemistry, 20(21):6195-6200 (Oct. 16, 1981).
D. Zevin-Sonkin et al, "Molecular Cloning of the Bovine Thymopoietin Gene and its Expression in Different Calf Tissues: Evidence for a Predominant Expression in Thymocytes", Immunol. Lett., 31:301-310 (Jan. 12, 1992).
R. Basch et al, "Induction of T-Cell Differentiation in Vitro by Thymin, a Purified Polypeptide Hormone of the Thymus", Proc. Natl. Acad. Sci. USA, 71(4):1474-1478 (Apr. 1974) [Basch I].
D. Schlesinger et al, "Chemical Synthesis of a Peptide Fragment of Thymopoietin II that Induces Selective T Cell Differentiation", Cell, 5:367-370 (Aug. 1975) [Schlesinger II].
R. A. Basch et al, "Thymopoietin-Induced Acquisition of Responsiveness to T Cell Mitogens", Cell. Immunol., 20:218-228 (publ. Dec. 1975; mailing date Jan. 7, 1976) [Basch II].
G. Goldstein et al, "Thymopoietin and Myasthenia Gravis: Neostigmine-Responsive Neuromuscular Block Produced in Mice by a Synthetic Peptide Fragment of Thymopoietin", Lancet, 2:256-262 (Aug. 9, 1975) [Goldstein III].
G. Sunshine et al, "Thymopoietin Enhances the Allogeneic Response and Cyclic GMP Levels of Mouse Peripheral, Thymus-Derived Lymphocytes", J. Immunol., 120(5):1594-1599 (May 1978).
R. Brown et al, "Immunoreactive Thymopoietin in the Mouse Central Nervous System", Brain Research, 381:237-243 (Aug. 6, 1986).
T. Audhya et al, "Contrasting Biological Activities of Thymopoietin and Splenin, Two Closely Related Polypeptide Products of Thymus and Spleen", Proc. Natl. Acad. Sci. USA, 81:2847-2849 (May 1984) [Audhya II].
T. Audhya et al, "Isolation and Complete Amino Acid Sequence of Human Thymopoietin and Splenin", Proc. Natl. Acad. Sci. USA, 84:3545-3549 (Jun. 1987) [Audhya III].
G. Goldstein, "Lymphocyte Differentiations Induced by Thymopoietin, Bursopoietin and Ubiquitin", Molecular Control of Proliferation and Differentiation, Academic Press, Inc., pp. 197-202 (Feb. 1978) [Goldstein IV].
G. Goldstein et al, "Thymopoietin and Bursopoietin: Induction Signals Regulating Early Lymphocyte Differentiation", Cold Spring Harbor Symposia on Quantitative Biology, vol. XLI, pp. 5-8, Cold Spring Harbor Laboratory (1977) [Goldstein V].
M. Quik et al, "Evidence for Thymopoietin and Thymopoietin/alpha-bungarotoxin
icotinic Receptors within the Brain", Proc. Natl. Acad. Sci. USA, 88:2603-2607 (Mar. 1991) [Quik I].
M. Quik et al, "Thymopoietin Inhibits Function and Ligand Binding to Nicotinic Receptors at the Neuromuscular Junction", J. Pharm. Exp. Therm., 254(3):1113-1119 (Jul. 1990) [Quik II].
M. Quik et al, "Rapid Communication--Thymopoietin, a Thymic Polypeptide, Specifically Interacts at Neuronal Nicotinic alpha-Bungarotoxin Receptors", J. Neurochemistry, 53(4):1320-1323 (Sep. 12, 1989) [Quik III].
F. Revah et al, "Calcium-Dependent Effect of the Thymic Polypeptide Thymopoietin on the Desensitization of the Nicotinic Acetylcholine Receptor", Proc. Natl. Acad. Sci. USA, 84:3477-3481 (May 1987).
Culler Michael D.
Goldstein Gideon
Harris Crafford A.
Setcavage Diane R.
Shenbagamurthi Ponniah
Immunobiology Research Institute, Inc.
Teng Sally P.
Walsh Stephen G.
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