Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-06-10
1995-01-03
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, C07K 1300
Patent
active
053788087
ABSTRACT:
The invention described encompasses an isolated DNA sequence encoding all or a portion thereof of a cell surface receptor murine and human erythropoietin (hereinafter EPO-R), along with the isolated polypeptide expressed by the DNA sequence (i.e., isolated EPO-R). The invention also encompasses host cells containing the above-described DNA sequence, preferably, host cells which express the polypeptide encoded by the DNA sequence (EPO-R) at a significantly higher level than that produced by normal red blood cell precursors. The invention further encompasses DNA sequences encoding secreted forms of the human EPO-R and polypeptides corresponding thereto. The EPO-receptor in all of the disclosed forms can be used as models for designing drugs or in pharmaceutical compositions for treating anemias.
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Sawyer et al., PNAS 84:3690-3694 (1987).
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Sims et al., Science 241: 585-588 (1988).
Seed et al., PNAS 84:3365-3369 (1987).
Winkelmann et al., Blood 76(1):24-30 (1990).
D'Andrea Alan
Jones Simon S.
Wong Gordon G.
Brown Scott A.
DesRosier Thomas J.
Draper Garnette D.
Genetics Institute Inc.
McDaniels Patricia A.
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