Recombinant constructs and their use in reducing gene...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S023100, C536S024100, C536S024500

Reexamination Certificate

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07897383

ABSTRACT:
Recombinant constructs useful for reducing the expression of endogenous mRNA and any substantially similar endogenous mRNA are disclosed. In particular, a recombinant construct comprising, inter alia, a suitable nucleic acid sequence and its reverse complement can be used to alter the expression of any homologous, endogenous RNA (i.e., the target RNA) which is in proximity to this suitable nucleic acid sequence.

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E. Cristofaro

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