Reagent including an osmium-containing redox mediator

Details Reagent including an osmium-containing redox mediator Reagent including an osmium-containing redox mediator

1996-12-20

1998-12-08

Leary, Louise

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 14, 435 25, 435817, 420461, 356 39, 356344, 204193, 204450, C12Q 100, C12Q 154, C12Q 126

Patent

active

058467025

ABSTRACT:
A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solubility in aqueous medium. These mediators are particularly useful as a component of a reagent used in an electrochemical biosensor, wherein the biosensor is useful for measuring analytes from a biological fluid, such as blood.

REFERENCES:
patent: 4293310 (1981-10-01), Weber
patent: 4381978 (1983-05-01), Gratzel et al.
patent: 4526661 (1985-07-01), Steckhan et al.
patent: 4545382 (1985-10-01), Higgins et al.
patent: 4711245 (1987-12-01), Higgins et al.
patent: 4954414 (1990-09-01), Adain et al.
patent: 5288636 (1994-02-01), Pollmann et al.
Cl!.sup.+/2+ Complexed Poly(1-vinylimidazole Films"; 1993, pp. 3512-3517, Anal. Chem. Month not available.
Forster et al.; "Synthesis, Characterization, and Properties of a Series of Osmium-and Ruthenium-Containing Metallopolymers"; 1990; pp. 4372-4377; Macromolecules Month not available.
Zakeeruddin et al.; "Towards Mediator Design: Characterization of Tris-(4,4'-Substituted-2,2'-Bipyridine) Complexes of Iron (II), Ruthenium (II) and Osmium (II) as Mediators for Gluclose Oxidase of Aspergillus Niger and Other Redox Proteins"; 1992, pp. 253-283, J. Electroanal. Chem. Month not available.
Collin et al.; "Anodic Electropolymerization of Films of Polypyrrole Functionalized with Metal Terpyridyl Redox Centres"; 1990; pp. 75-87; J. Electroanal. Chem. Month not available.
Garguilo et al.; "Amperometric Sensors for Peroxide, Choline, and Acetylcholine Based on Electron Transfer between Horseradish Peroxidase and a Redox Polymer"; 1993; pp. 523-528; Anal. Chem. Month not available.
Pishko et al.; "Direct Electrical Communication Between Graphite Electrodes and Surface Adsorbed Glucose Oxidase/Redox Polymer Complexes"; 1990; pp. 82-84; Angew. Chem. Int. Ed. Engl. Month not available.
Geraty et al., "Characterization, Electrochemical and Photochemical Properties of Ruthenium Containing Poly-N-vinylimidazole Coatings", 1984, pp. 389-393, J. Electroanal. Chem. Month not available.
Surridge et al., J. Phys. Chem., vol. 98(3), pp. 917-923, 1994 Month not available.

Affiliated with

Also associated with

Rating

Reagent including an osmium-containing redox mediator does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reagent including an osmium-containing redox mediator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reagent including an osmium-containing redox mediator will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-175611