Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-16
2007-10-16
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S423000, C514S365000, C514S411000, C514S375000, C514S002600, C514S075000, C514S080000, C514S092000, C514S336000
Reexamination Certificate
active
11786290
ABSTRACT:
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for multiphoton imaging has been disclosed. These fluorophores are based upon the fluorene ring system, known to exhibit high fluorescence quantum yields, typically >0.7, and possess high photostability. They have been functionalized with moieties to act, e.g., as efficient amine-reactive fluorescent probes for the covalent attachment onto, e.g., proteins and antibodies. The synthesis and the single-photon spectral characteristics, as well as measured two-photon absorption cross sections of the reactive fluorophores in solution are presented. Spectral characterizations of bovine serum albumin (BSA) conjugated with the new reactive probe is presented.
REFERENCES:
Katherine Schafer, et al., “Fluorescent dyes for multiphoton bio-imaging applications”, Dec. 2004 Proceedings of SPIE, vol. 5329.
Kevin Belfield, et al., “Reactive two-photon fluorescent probes for biological imaging”, Aug. 3, 2003, pp. 91-95, Proceedings of SPIE, vol. 5211.
Belfield Kevin D.
Schafer Katherine J.
Barker Michael P.
Law Offices of Brian S. Steinberger , P.A.
McKane Joseph K.
Morlin Joyce P.
Research Foundation of The University of Central Florida, Inc.
LandOfFree
Reactive probes for two-photon fluorescent imaging and sensing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reactive probes for two-photon fluorescent imaging and sensing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reactive probes for two-photon fluorescent imaging and sensing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3901177