Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Reexamination Certificate
2011-03-22
2011-03-22
Cheu, Jacob (Department: 1641)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
C435S007100
Reexamination Certificate
active
07910065
ABSTRACT:
Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an observable signal indicating a value of a parameter associated with the chemical reaction, e.g., the concentration of a reaction product. Because cell viability is not compromised, the cell may be stimulated (e.g., by subjection to an agonist or antagonist, a pathogen, a pharmaceutical compound, or a potential toxin) so as to affect the reaction under study.
REFERENCES:
patent: 4272484 (1981-06-01), Lubbers
patent: 4272485 (1981-06-01), Lubbers et al.
patent: 4357311 (1982-11-01), Schutt
patent: 4379041 (1983-04-01), Petranek et al.
patent: 4945171 (1990-07-01), Haugland et al.
patent: 5057431 (1991-10-01), Lubbers et al.
patent: 5128019 (1992-07-01), Karpf et al.
patent: 5132095 (1992-07-01), Koshiishi et al.
patent: 5447837 (1995-09-01), Urnovitz
patent: 5494640 (1996-02-01), Simon et al.
patent: 5691205 (1997-11-01), Kawabata et al.
patent: 5908624 (1999-06-01), Scott et al.
patent: 6143558 (2000-11-01), Kopelman et al.
patent: 6210551 (2001-04-01), Osman et al.
patent: 6379955 (2002-04-01), Kopelman et al.
patent: 6699465 (2004-03-01), Scott
patent: 2002/0155600 (2002-10-01), Kopelman et al.
patent: 2003/0157535 (2003-08-01), Berkovic
patent: 2003/0213691 (2003-11-01), Peper et al.
patent: 2003/0217920 (2003-11-01), Peper et al.
patent: 2004/0058384 (2004-03-01), Bakker et al.
patent: 2004/0058458 (2004-03-01), Anker et al.
patent: 2004/0146944 (2004-07-01), Fang et al.
patent: 2005/0011760 (2005-01-01), Bakker et al.
patent: 2006/0008924 (2006-01-01), Anker et al.
patent: WO-99/45357 (1999-09-01), None
patent: WO-01/08660 (2001-02-01), None
patent: WO-2004/083902 (2004-09-01), None
Brasuel et al. (Anal Chem 2001 vol. 73, p. 2221-2228).
Buck et al. (Talanta 2004 vol. 63, p. 41-59).
Barker et al., “Radiometric and Flourescense-Lifetime-Based Biosensors Incorporating Cytochromec'and the Detection of Extra- and Intracellular Macrophage Nitric Oxide,”Anal. Chem., vol. 71, No. 9, May 1, 1999, pp. 1767-1772.
Buck et al., “Nanoscale Probes Encapsulated by Biologically Localized Embedding (PEBBLEs) for Ion Sensing and Imaging in Live Cells,”Talanta, vol. 63, No. 1, May 10, 2004, pp. 41-59.
Bühlmann et al., “Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors,”Chem. Rev., vol. 98, Jan. 1, 1998, pp. 1593-1687.
Dubach et al., “Flourescent Ion-Selective Nanosensors for Intracellular Analysis with Improved Lifetime and Size,” Nano Letters, vol. 7, No. 6, Jun. 2007, pp. 1827-1831.
Kohls et al., “Setup of a Fiber Optical Oxygen Multisensor-System and its Applications in Biotechnology,”Sensors and Actuators B, vol. 70, (2000), pp. 121-130.
Sigworth et al., “Microchip Technology in Ion-Channel Research,”IEEE Transactions on Nanobioscience, vol. 4, No. 1, Mar. 2005, pp. 121-127.
International Search Report for PCT Application No. PCT/US2006/036040, mailed Aug. 29, 2008, 4 pages, 2006.
Written Opinion for PCT Application No. PCT/US2006/036040, mailed Aug. 29, 2008, 7 pages.
European Search Report for European Patent Application No. 06 851 882.8, mailed Mar. 31, 2009, 5 pages.
Examination Report mailed Mar. 11, 2010 in European Patent Application No. 06851882.8 (5 pages).
Cheu Jacob
Goodwin & Procter LLP
The Charles Stark Draper Laboratory Inc.
LandOfFree
Reaction sensing in living cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reaction sensing in living cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reaction sensing in living cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2701384