Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1990-12-03
1993-07-20
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 514912, 514913, 215231, 215263, 215265, 215294, 215301, 215DIG3, A61K 900, A61K 3114, A61J 100, B65D 3916
Patent
active
052291278
ABSTRACT:
Quick miosis with 24 hour control of intraocular pressure of patients undergoing extracapsular cataract extraction surgery is achieved by applying to the eyes of the patient during surgery acetylcholine as a first miotic agent and carbachol as a second miotic agent. Acetylcholine provides quick miosis while carbachol enhances the miotic effect while providing post-surgery control of intraocular pressure. The two miotic agents can be dissolved in a common saline carrier. The two agents can be combined in a unit dosage package by disposing acetylcholine in powder form in a first compartment and a solution of carbachol in a second compartment. The combined miotic agent of the invention is especially useful when substances which raise IOP such as viscoelastic agents are used during ocular surgery and/or with sensitive patients who enter the surgery with elevated pressure such as those suffering from glaucoma.
REFERENCES:
patent: 3870791 (1975-03-01), Haddad et al.
patent: 4405627 (1983-09-01), Masi et al.
patent: 4459309 (1984-07-01), Chiou
patent: 4490379 (1984-12-01), Podos et al.
patent: 4665094 (1987-05-01), Baldwin et al.
patent: 4853224 (1989-08-01), Wong
patent: 5009892 (1991-04-01), McKinzie
Gormaz, A., Ocular Tension After Cataract Surgery, American Journal of Ophthalmology, 43:832, 1962.
Rich, W. J. C. C., Intraocular Pressure and Wound Closure After Cataract Extraction, Trans. Ophthalmol. Soc., U.K. 88:437, 1968.
Rich, W. J. C. C., Further Studies on Early Post-Operative Ocular Hypertension Following Cataract Extraction, Trans. Ophthalmol. Soc., U.K. 89:639, 1969.
Olivius, E., and Thornburn, W., Intraocular Pressure After Cataract Surgey with Healon, Am. Intraocular Implant Soc. J. 11:480, 1985.
Cherfan, G. M., Rich, W. J. and Wright, G., Raised Intraocular Pressure and Other Problems with Sodium Hyaluronate and Cataract Surgery, Trans. Ophthalmol. Soc., U.K., 103:277, 1983.
Obstbaum, S. A. and Galin, M. W., The effects of Timolol on Cataract Extraction and Intraocular Pressure, Am. J. Ophthalmol., 88:117, 1979.
Tomoda, T., Tuberville, A. W. and Wood, T. O., Timolol and Postoperative Intraocular Pressure, Am. Intraocul. Implant Soc.J., 10:180, 1984.
Ruiz, R. S., Wilson, C. A., Mugrove, K. H. and Prager, T. C., Management of Increased Intraocular Pressure After Cataract Extraction, Am. J. Ophthamol., 103:487, 1987.
Beasley, H., Miotics in Cataract Surgery, Arch, Ophthalmol., 88:49, 1972.
Douglas, G. R., A Comparison of Acetylcholine and Carbachol Following Cataract Extraction, Can. J. Ophthalmol. 8:75, 1973.
Holland, R. H., Drance, S. M., & Schulzer, M., The Effect of Intracramerol Carbachol on Intraocular Pressure After Cataract Extraction, Am. J. Ophthalmol, 104:225, 1987.
Hollands, R. H., Drance, S. M., & Schulzer, M., The Effect of Acetylcholine on Early Postoperative Intraocular Pressure, Am. J. Ophthalmol., 103:749, 1987.
Hayreh, S. S., Anterior Ischemic Optic Neuropathy, IV, Occurrence After Cataract Extraction, Arch. Ophthalmol., 98:1410, 1980.
Yee; R. W. and Edelhauser, H. F., Comparison of Intraocular Acetylcholine and Carbachol, J. Cataract Refract Surg., 12:18, 1986.
McKinzie, J. W. & Boggs, Jr., M. B., Comparison of Postoperative Intraocular Pressures After Use of Miochol and Miostat, J. Cataract Refract. Surg. 15:185, 1989.
Linn, D., Zimmerman, T., Nardin, G., Yung, R., Berberich, S., DuBiner, H., Fuque, M., Effect of Intracameral Carbachol on Intraocular Pressure After Cataract Extraction, Am. J. Ophthalmol., 107:133-136, Feb. 1989.
Ruiz, R., Rhem, M., & Prager, T., Effects of Carbachol and Acetylcholine on Intraocular Pressure After Cataract Extraction, Am. J. Opthalmol., 107:7-10, Jan. 1989.
A. Pilz, J. Pilz & W.-D. Ulrich, Interference of Directly Acting Cholinergics on the Isolated Sphincter Pupillae and Ciliary Muscle, Folia Opthal.4(1979), 34-45.
Wood, T., Effect of Carbachol on Postoperative Intraocular Pressure, J. Cataract Refract. Surg.-vol. 14, Nov. 1988.
McDonald, T., Beasley, C., Borgmann, A., & Roberts, D., Intraocular Administration of Carbamylcholine Chloride, Annals of Ophthalmol., Oct. -Nov. 1969.
O'Brien, C. S., Swan, K. C., Carbaminoylcholine Chloride in the Treatment of Glaucoma Simplex, Dept. of Ophthalmol., State University of Iowa, College of Medicine.
Jacobs Marvin E.
Page Thurman K.
Webman E. J.
LandOfFree
Rapid miosis with control of intraocular pressure using a mixtur does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rapid miosis with control of intraocular pressure using a mixtur, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapid miosis with control of intraocular pressure using a mixtur will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1758898