Rapamycin carbonate esters as immuno-suppressant agents

Details Rapamycin carbonate esters as immuno-suppressant agents Rapamycin carbonate esters as immuno-suppressant agents

1992-11-19

1993-11-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 90, 540456, 540452, A61K 31395, C07D49106

Patent

active

052603008

ABSTRACT:
Carbonate esters with rapamycin at position 42 or positions 31 and 42 have been shown to have immunosuppressant properties and are useful in the treatment of transplant rejections and autoimmune diseases. These esters are represented by the formula below: ##STR1## wherein: R.sup.1 and R.sup.2 are independently H or --COOR.sup.3 but both R.sup.1 and R.sup.2 cannot be H, and

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