Rapamycin analog as immunosuppressants and antifungals

Details Rapamycin analog as immunosuppressants and antifungals Rapamycin analog as immunosuppressants and antifungals

1992-04-29

1992-12-08

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540456, A61K 31395, C07D49816

Patent

active

051698510

ABSTRACT:
Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosupressant, antifungal, and antiinflammatory activities.

REFERENCES:
patent: 5118678 (1992-06-01), Kao et al.

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