RANTES mutants and therapeutic applications thereof

Details RANTES mutants and therapeutic applications thereof RANTES mutants and therapeutic applications thereof

2007-01-16

2007-01-16

Li, Bao Qun (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S085100, C424S085200, C424S093100, C435S320100, C435S069100, C536S023100

Reexamination Certificate

active

10400487

ABSTRACT:
RANTES mutants characterised by the substitution or addition of amino acids at the N-terminal of RANTES wild-type sequence and in the N-loop and/or 40's loop regions of RANTES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.

REFERENCES:
patent: 6159711 (2000-12-01), Proudfoot et al.
patent: WO 96/17935 (1996-06-01), None
patent: WO 97/44462 (1997-11-01), None
patent: WO 98/13495 (1998-04-01), None
Lazar et al. Molecular and Cellular Biology 1988, vol. 8, No. 3, pp. 1247-1252.
Smilek et al. Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 9633-9637.
Proudfoot et al. J. Biochem. Chemis. 1999, vol. 274, No. 45, pp. 32478-32485.
Littman D. Cell 1998, vol. 93, pp. 677-680.
Skelton et al. Biochemistry 1995, vol. 34, pp. 5329-5342.
Schall et al. J. Immunol. 11988, vol. 141, No. 3, pp. 1018-1025.
Oravecz et al.,J. Exp. Med., 186:1865-1872 (1997).
Mosier et al.,J. Virol., 73:3544-3550 (1999).
Trkola et al.,J. Virol., 73:6370-6379 (1999).
Shepard et al.,Nature, 294:563-565 (1981).
Deepika R. Pakianathan et al., Distinct but overlapping epitopes for the interaction of a CC-chemokinewith CCR1, CCR3, and CCR5,Biochemistry, 36:99642-9648 (1997) Easton, PA, US.
Chun-Wa Chung et al, The three-dimensional solution structure of rantes,Biochemistry, 34:9307-9314 (1995) Easton, PA, US.
Gong JH et al., Rantes and MCP-3 antagonists bind multiple chemokine receptors,Journal of Biological Chemistry, 271(18)10521-10527 (1996).
Skelton NJ et al., Proton NMR assignments and solution conformation of rantes, a chemokine of the C—C type,Biochemistry, 34(16)5329-5342 (1995).

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