Cyclopenta[b]indole derivatives as sPLA 2 inhibitors

Details Cyclopenta[b]indole derivatives as sPLA 2 inhibitors Cyclopenta[b]indole derivatives as sPLA 2 inhibitors

2007-01-09

2007-01-09

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S134000, C548S135000, C548S427000, C548S439000, C548S448000, C514S411000

Reexamination Certificate

active

10484015

ABSTRACT:
A novel class of tricyclic compounds of the following formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.

REFERENCES:
patent: 0 950 661 (1999-10-01), None
patent: WO 00 07591 (2000-02-01), None
D. J., Davies, “Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent 'b!indoles, tetrahydrocarbazoles and hexahydrocyclohept 'b!indoles,”J. Med. Chem., vol. 41, No. 4, pp. 451-467 (1998); XP002215114.

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