Radiolabeled thrombus imaging agents

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

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530300, 514 12, 514 13, 514 14, 514 15, 424 111, 424 169, 424 165, A61K 5108, A61K 3816

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active

058861424

ABSTRACT:
This invention relates to a radiodiagnostic agent to image arterial and venous thrombi, pulmonary emboli and lesions of atherosclerosis. A composition for a thrombus imaging agent, a method and kit for preparing a thrombus imaging agent, and a radiolabeling reagent for preparing the thrombus imaging agent are provided. Methods of using the thrombus imaging agent to detect thrombi are also provided.

REFERENCES:
patent: 4917878 (1990-04-01), Thakur
patent: 5011676 (1991-04-01), Thakur
patent: 5218128 (1993-06-01), Dean et al.
patent: 5508020 (1996-04-01), Dean et al
patent: 5552525 (1996-09-01), Dean
Andreu, D. et al., Formation of Disulfide Bonds in Synthetic Peptides and Proteins, Pennington, W., Ed., Humana Press, Totowa, NJ 1994, pp. 91-169.
Asch et al., "Thrombospondin Sequence Motif (CSVTCG) is Responsible for CD346 Binding", Biochem. Biophy. Res. Comm. 1992, 182, 1208-1217.
Baenziger, N.L. et al., "A Thrombin-Sensitive Protein of Human Platelet Membranes", Proc. Natl. Acad. Sci. USA 1971, 68, 240-243.
Chen et al., "Human Microvascular Endothelial Cells Adhere to Thrombospondin-1 via an RGD/CSVTCG Domain Independent Mechanism", J. Invt. Dermatol. 1996, 106, 215-220.
Ganguly, P., "Isolation an Properties of a Thrombin-sensitive Protein from Human Blood Platelets", J. Biol. Chem. 1971, 246, 4286-4290.
Knight, L.C., "Radiopharmaceuticals for Thrombus Detection", Seminars in Nucl. Med. 1990, XX:52-67.
Knight, L.C. et al., "Thrombus Imaging with Technetium-99m Synthetic Peptides Based upon the Binding Domain of a Monoclonal Antibody to Activated Platelets", J. Nucl. Med. 1994, 35, 282-288.
Koblik, P.D. et al., "Current status of immunoscintigraphy in the detection of thrombosis and thromboembolism", Seminars in Nucl. Med. XIX:221-231, 1989.
Lawler et al., "The Structural and Functional Properties of Thrombospondin", Blood 1986, 67, 1197-1209.
Line, B.R. et al., "Phase I Trial of DMP 444, A New Thrombus Imaging Agent", J. Nucl. Med. 1996, 37, 117P.
Pearson, D.A., "Thrombus Imaging Using Technetium-99m-Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies", J. Med. Chem. 1996, 39, 1372-1382.
Thakur, M.L. et al., "Indium-111 Labeled Platelets: Studies on Preparation and Evaluation of In Vitro and In Vivo Functions", Thrombosis Research 1976, 9, 345-354.
Thakur et al., "Vapriotide labeled with Tc-99m for imaging tumors: Preparation and preliminary evaluation", Intl. J. Oncol. 1996, 9, 445-451.
Thakur, M.L., "Scintigraphic imaging of venous thrombosis: the state of the art", Thrombotic and Hematologic Disorders 1992, 5, 29-36.
Thakur, M.L. "Radiolabeled monoclonal antibodies for imaging and therapy", S.C. Srivastava (Ed.), Plenum Publishing Co., NATO ASI, series 152, 1988.
Tuszynski, G.P. et al., "Biological Activities of Peptides and Peptide Analogues Derived from Common Sequences Present in Thrombospondin, Properdin, and Malarial Proteins", J. Cell Biol. 1992, 116, 209-217.
Veber, D., "Acetamidomethyl. A Novel Thiol Protecting Group for Cysteine", et al. J. Am. Chem. Soc. 1972, 94, 5456-5461.
Wang et al, "The Effect of Thrombospondin on Oral Squamous Carcinoma Cell Invasion of Collagen", Am. J. Surg. 1995, 170, 502-505.
Knight et al., J. Nucl. Med. vol. 35, No. 2, Feb. 1994, pp. 282-288.
Chen et al., J. Invest. Dermatol. vol. 106, pp. 215-220, 1996.

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