Radiolabeled colloid compositions and method for preparing same

Details Radiolabeled colloid compositions and method for preparing same Radiolabeled colloid compositions and method for preparing same

1989-12-27

1991-10-29

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 534 11, 600 3, 600 4, 252635, A61K 4300, A61N 512

Patent

active

050614762

ABSTRACT:
Radiolabeled colloid compositions and a method for the preparation of radionuclide-colloid compositions useful in the treatment of rheumatoid arthritis are disclosed. A radionuclide selected from the group consisting of Sm-135, Ho-166, In-155m, Y-90, Gd-159 La-140, Lu-177, or Yb-175 is sorbed to a previously prepared iron-hydroxide colloid. The radiolabeled colloid compositions are comprised of spherical aggregations containing greater than 50% of the radioactive metal in iron-hydroxide particles. The method produces stable radionuclide iron-hydroxide compositions which are useful in therapeutic procedures such as radiation synovectomy.

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